fgf-23, klotho and vitamin d levels in scleroderma
نویسندگان
چکیده
background: scleroderma is a chronic connective tissue disease of unknown etiology. vitamin d and parathyroid hormone (pth) that play particular functions in calcium and phosphate homeostasis may be involved in the etiology of this disorder. klotho, the co-receptor of the fibroblast growth factor 23 (fgf-23), can interfere with calcium and phosphate metabolism. the purpose of this study was to evaluate serum klotho, fgf-23, intact pth (ipth) and vitamin d levels in scleroderma patients compared with the healthy controls. methods: the study was performed in biotechnology research center, tabriz university of medical sciences (tums) from 2014-2015. sixty scleroderma patients based on the classification criteria of systemic sclerosis and 30 age- and sex-matched healthy controls were included in this study. serum klotho, fgf-23, 25-hydroxy vitamin d (25-oh vit d), and ipth levels were analyzed using elisa. results: serum levels of klotho and 25-oh vit d in the scleroderma patients were lower than those in the healthy controls ( p ˂0.001). in addition, scleroderma patients had higher serum ipth levels than the controls ( p <0.001). there was no significant difference in serum fgf-23 levels between the patients and controls ( p =0.202). conclusion: the decreased serum klotho, 25-oh vit d, and increased ipth levels in the scleroderma patients may be associated with the pathogenesis of this disease and could be considered a future therapeutic target.
منابع مشابه
FGF-23, Klotho and Vitamin D Levels in Scleroderma
BACKGROUND Scleroderma is a chronic connective tissue disease of unknown etiology. Vitamin D and parathyroid hormone (PTH) that play particular functions in calcium and phosphate homeostasis may be involved in the etiology of this disorder. Klotho, the co-receptor of the fibroblast growth factor 23 (FGF-23), can interfere with calcium and phosphate metabolism. The purpose of this study was to e...
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Background & Aims: Scleroderma is a chronic connective tissue disease with unknown etiology. Vitamin D, a necessary hormone that plays a particular function in the calcium and phosphate homeostasis, is involved in etiology of this disorder. Klotho, co-receptor of fibroblast growth factor 23 (FGF-23), can interfere in calcium and phosphate metabolism. The purpose of this study was to determ...
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عنوان ژورنال:
iranian journal of public healthجلد ۴۶، شماره ۴، صفحات ۵۳۰-۵۳۶
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